|The Devil Within|
|Season 5, Episode 1|
|Twilight||Fear The Fever|
PART 1 OF 3: KARA REMEMBERS- Apokaliptian torturer Desaad is restored to life and comes into conflict with Team Supergirl. When Kara discovers the reason for his resurrection, she doubts herself and begins hallucinating Darkseid. Lena has a clandestine meeting with Lillian, while Alex helps James on the streets of National City. Clark and Maggie interrogate Reign.
- Melissa Benoist as Kara Danvers/Supergirl/Darkseid
- Chyler Leigh as Alex Danvers
- Jeremy Jordan as Winslow Schott
- Katie McGrath as Lena Luthor
- Odette Annable as Reign
- Tyler Hoechlin as Clark Kent/Superman
- Floriana Lima as Maggie Danvers
- with Claire Holt as Karen Starr/Power Girl
- and Mehcad Brooks as James Olsen/Guardian
Special Guest StarsEdit
- Brenda Strong as Lillian Luthor
- DB Woodside as Desaad
- Amy Jackson as Imra Ardeen
- and Dianna Agron as Major Raya Zod-El
- Antagonist: Desaad
- Darkseid appears as Kara's hallucinations.
- Darkseid were last seen in Family.
- Desaad was last seen in The Prisoner.
- 1st episode this season to feature all main characters.
- This is the fifth season premiere.
- This is the 5th season premiere to feature Kara, Alex, Astra, and Clark. Brooks has also appeared in all 5 premieres, but did not portray the real James Olsen in Lines.
- This is the 4th season premiere to feature Lena.
- This is the 3rd season premiere to feature Maggie, Karen, and Lillian.
- This is the 2nd season premiere to feature Jeremiah.
- First season premiere to not feature Winn.
- This episode takes place on November 3, 2020.