|The Animal Inside of You|
|Season 8, Episode 1|
|I Will Always Protect You, No Matter What||Eat Your Fill|
PART 1: REGIME CHANGE- Mary Seward returns and makes short work of her opposition at L-Corp, causing Lena Luthor to retaliate. However, she could be playing directly into Mary's hands. Meanwhile, Lucy Lane considers becoming Superwoman once more and Diana Prince moves to National City.
- Melissa Benoist as Kara Danvers/Supergirl
- Chyler Leigh as Alex Danvers
- Katie McGrath as Lena Luthor
- Odette Annable as Samantha Arias
- Olivia Wilde as Susannah Russo
- Adelaide Kane as Ava Blackwood
- Minka Kelly as Dawn Granger
- with Emmy Rossum as Zaora Dru-Zod (credit only)
- and Michael Rosenbaum as Lex Luthor (Earth-30) (credit only)
- Brenda Strong as Lillian Luthor
- Troian Bellisario as Mary Seward
- Dichen Lachman as Talia al Ghul
- Emmanuelle Chriqui as Sarah Essen
- Rachel Nichols as Onyx
- Marie Avgeropoulos as Diana, Princess of Themyscira
- Teressa Liane as Mary Louise Fairchild
- Scarlett Byrne as Nora Fairchild
- Brit Morgan as Livewire
- Lili Reinhart as Aethryr
- Tamzin Merchant as Lyra Strayd
- and Oded Fehr as Ra's al Ghul
- Antagonist: Mary Seward
- E30 Lex and Zaora does not appear in this episode.
- This episode is Lena-centric.
- First appearance of Ava Blackwood.
- The first episode to not feature Clark, Karen, and J'onn as series regulars.