|Season 5, Episode 13 (95)|
- Melissa Benoist as Kara Danvers/Supergirl & Nyssa Zor-El
- Chyler Leigh as Alex Danvers & Rao
- Katie McGrath as Lena Luthor
- Laura Benanti as Alura Zor-El & Astra In-Ze
- Odette Annable as Reign & Samantha Arias
- Tyler Hoechlin as Kal-El
- Olivia Wilde as Susannah Russo
- Jenna Dewan as Lucy Lane & Rao
- with Claire Holt as Karen Starr
- and Mehcad Brooks as James Olsen & Rao
Special Guest StarEdit
- Zachary Quinto as General Dru-Zod
- Emmy Rossum as Zaora Dru-Zod
- Paige Turco as Lara Lor-Van
- Sarah Shahi as Ursa
- Harry Lennix as Commander Gor
- Julian Sands as Jor-El
- Robert Gant as Zor-El
- Daniel Sharman as Lor-Zod
- Georgina Campbell as Asha Del-Nar
- and Dianna Agron as Major Raya Zod-El
- Antagonist: Reign
- 12th episode this season to feature all main characters.
- Kara, Alex, Lena, and Reign are the only characters to appear in the "real world" segment of this episode.
- Zod and Ursa were last seen in Twilight.
- Jor-El, Lara and Alura were last seen in City On Fire.
- Lor-Zod was last seen in The House of Zod.
- Gor was last seen in The Fall of Kandor as a corpse.
- This episode takes place on December 21-22, 2020.
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